I just came across this podcast and started listening to it. So far I'm really enjoying it. It's nice to hear more of the human, personal side to "the software life". And I enjoy the music interspersed. Check it out.
I also listen to Scott's Hanselminutes but it's a totally different podcast, much more technical and Microsoft focused. (I use it to keep up on Microsoft technology, which I feel I should be aware of even if I tend to avoid it.)